The progress of recombinant gene technology has enabled us to produce proteins which 
originally were only found in very small quantities in the body. These proteins are now 
used in a variety of industries, ranging from human pharmaceuticals to diagnostics. The 
recent decoding of the human genome by both public and private research institutes has 
created many new and exciting developments. For example using information from the genome 
sequence to develop new drugs. The genome sequence however is only the start. From this 
information we now must tackle the challenging task of analyzing protein structure, 
function, activity etc. Due to this fact the importance protein expression and production 
is clear. 
 
ProtienExpress co. Ltd. (PE) has positioned itself so it can take full advantage of 
these developments. We have been developing expertise in the field of protein production 
for over 20 years. We are continuing to carry out research in this field in order to 
further enhance the technology we already possess. 
 
PE was established from the biotechnology research department of Higeta Shoyu co. In 
Higeta this department was involved biotechnology research since the early 1980's based 
on know how developed over 400 years of soy sauce fermentation. One of the successes which 
resulted from this research was the creation of the Bacillus brevis protein 
expression system. This protein expression system was subsequently used for the production 
of epidermal growth factor (EGF) on an industrial scale, as part of a commercial venture 
which included, among others, CSIRO ( Australian national research institute ). 
 
Through its technology and expertise PE aims to establish itself as a leading company 
in the area of protein production and research. 
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